“Inhibiting the Inhibitors” to Support Axonal Regeneration

Inhibiting the inhibitors

It has been known for many years that the immune system can actively respond to (pre)neoplastic cells and prevent oncogenesis (a concept known as cancer immunosurveillance). However, in most cases, antitumor immune responses are inefficient and neoplasms are allowed to establish. Indeed, effector T cells often infiltrate developing malignant lesions and may significantly influence the prognosis...

Inhibition of Axonal Regeneration*

Because axonal damage and loss are frequent phenomena of multiple sclerosis and other types of neurodegenerative diseases, and because the effects can be devastating clinically, attention has been focused on repair to axons. However, axon regeneration appears to be inhibited via a variety of possible cellular pathways and molecules. In the following article, several of these pathways are examin...

Title Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3β activation

Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury

While it is well established that the axons of adult neurons have a lower capacity for regrowth, some regeneration of certain CNS populations after spinal cord injury (SCI) is possible if their axons are provided with a permissive substrate, such as an injured peripheral nerve. While some axons readily regenerate into a peripheral nerve graft (PNG), these axons almost always stall at the distal...

willingness to communicate in the iranian context: language learning orientation and social support

why some learners are willing to communicate in english, concurrently others are not, has been an intensive investigation in l2 education. willingness to communicate (wtc) proposed as initiating to communicate while given a choice has recently played a crucial role in l2 learning. it was hypothesized that wtc would be associated with language learning orientations (llos) as well as social suppo...